I just discovered a bizarre side effect when using ThickBox in conjunction with the Ajax UpdatePanel. Basically, I've got a second web form which I use ThickBox to load like a modal popup. When closing the popup form, I call a javascript function on the initial form which uses __doPostBack() to perform a partial page postback. In my code-behind, I respond to this postback by setting text on a label that is wrapped by an UpdatePanel. So far, everything works great. However, at this point I discover that other text boxes on the page that are outside of the UpdatePanel are suddenly disabled! I'm using VS2008 and .NET 3.5: